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KMID : 0882420100780020191
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Korean Journal of Medicine
2010 Volume.78 No. 2 p.191 ~ p.197
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The relationship between the ApoB/ApoA-I ratio and non-alcoholic fatty liver disease in prediabetic patients
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Lee Ji-Ae
Jang Seung-Hun
Min Jae-Hoon
Kim Tae-Wan
Jeong Woo-Shin
Shim Choong-Nam
Heo Woon-Je
Jung Mi-Youn
Lee Hyon-A
Cho Yong-Kyun
Hong Hyun-Pyo
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Abstract
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Background/Aims: The apolipoprotein B/A-I ratio (ApoB/A-I) is a powerful clinical indicator of atherosclerosis. Although numerous reports have shown the effect of non-alcoholic fatty liver disease (NAFLD) on cardiovascular disease, few reports have examined the relationship between NAFLD and the ApoB/A-I ratio. The aim of the study was to determine the association between NAFLD and the ApoB/A-I ratio in prediabetic patients.
Methods: This cross-sectional study was performed with data obtained from 701 patients (mean age, 47.9±9.6 years) diagnosed with prediabetes. Serum lipid profiles including lipoprotein, apolipoprotein, and calculated ApoB/A-I ratio as well as metabolic syndrome parameters such as fasting glucose and insulin were measured in each subject.
Results: Among the 701 patients, 340 (48%) had NAFLD. The number of male patients was 490 (NAFLD+, 276; and NAFLD-,214). The odds ratios for the prevalence of NAFLD increased according to the quartiles of the ApoB/A-I ratio (1.886, 2.245, and 2.587) (p<0.001).
Conclusions: The prevalence of NAFLD correlated with high ApoB/A-I ratio, suggesting that NAFLD increases the risk for atherosclerosis progression in male prediabetic patients.
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KEYWORD
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NAFLD, Apolipoprotein B, Apolipoprotein A-I, Prediabetes, Atherosclerosis
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